abstract：:Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammato...

journal_title：Neurotoxicology

authors： Khalilzadeh M,Panahi G,Rashidian A,Hadian MR,Abdollahi A,Afshari K,Shakiba S,Norouzi-Javidan A,Rahimi N,Momeny M,Dehpour AR

更新日期：2018-07-01 00:00:00

abstract：:Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of th...

journal_title：Neurotoxicology

authors： Mónaco NM,Bartos M,Dominguez S,Gallegos C,Bras C,Esandi MDC,Bouzat C,Giannuzzi L,Minetti A,Gumilar F

更新日期：2018-07-01 00:00:00

abstract：:Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many ...

journal_title：Neurotoxicology

authors： Llorens J,Callejo A,Greguske EA,Maroto AF,Cutillas B,Martins-Lopes V

更新日期：2018-05-01 00:00:00

abstract：:Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/...

journal_title：Neurotoxicology

authors： Arambula SE,Jima D,Patisaul HB

更新日期：2018-03-01 00:00:00

abstract：:Nerve agents (NAs) are potent organophosphorus (OP) compounds with applications in chemical warfare. OP compounds act by inhibiting acetylcholinesterase (AChE). Soman (O-pinacolyl methylphosphonofluoridate) is one of the most potent NAs. It is well known that small doses of NAs can be lethal, and that even non-lethal ...

journal_title：Neurotoxicology

authors： Lee K,Bohnert S,Wu Y,Vair C,Mikler J,Campbell Teskey G,Dunn JF

更新日期：2018-03-01 00:00:00

abstract：:Flavonoids are bioactive compounds that are known to be neuroprotective against glutamate-mediated excitotoxicity, one of the major causes of neurodegeneration. The mechanisms underlying these effects are unresolved, but recent evidence indicates flavonoids may modulate estrogen signaling, which can delay the onset an...

journal_title：Neurotoxicology

authors： Dos Santos Souza C,Grangeiro MS,Lima Pereira EP,Dos Santos CC,da Silva AB,Sampaio GP,Ribeiro Figueiredo DD,David JM,David JP,da Silva VDA,Butt AM,Lima Costa S

更新日期：2018-03-01 00:00:00

abstract：:Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the p...

journal_title：Neurotoxicology

authors： Pajarillo E,Johnson J Jr,Kim J,Karki P,Son DS,Aschner M,Lee E

更新日期：2018-03-01 00:00:00

abstract：:Manganese is an essential trace element, but also at high levels a neurotoxicant. Manganese neurotoxicity has been extensively studied since its discovery in highly exposed workers. The International conference MANGANESE2016 held at the Icahn School of Medicine at Mount Sinai in New York provided relevant updates on m...

journal_title：Neurotoxicology

authors： Lucchini RG,Aschner M,Landrigan PJ,Cranmer JM

更新日期：2018-01-01 00:00:00

abstract：:It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to eva...

journal_title：Neurotoxicology

authors： Foster ML,Bartnikas TB,Maresca-Fichter HC,Mercadante C,Dash M,Miller C,Dorman DC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the str...

journal_title：Neurotoxicology

authors： Casjens S,Dydak U,Dharmadhikari S,Lotz A,Lehnert M,Quetscher C,Stewig C,Glaubitz B,Schmidt-Wilcke T,Edmondson D,Yeh CL,Weiss T,Thriel CV,Herrmann L,Muhlack S,Woitalla D,Aschner M,Brüning T,Pesch B

更新日期：2018-01-01 00:00:00

abstract：:Chronic manganese (Mn) exposure can lead to neuroinflammation and neurological deficit, which resemble idiopathic Parkinson's disease (IPD). However, the precise mechanisms underlying Mn exposure-induced neurotoxicity remain incompletely understood. Microglia can become hyperactivated and plays a vital role in neuroin...

journal_title：Neurotoxicology

authors： Yin L,Dai Q,Jiang P,Zhu L,Dai H,Yao Z,Liu H,Ma X,Qu L,Jiang J

更新日期：2018-01-01 00:00:00

abstract：:Manganese (Mn) over-exposure in occupational settings is associated with basal ganglia toxicity and a movement disorder characterized by parkinsonism (i.e., the signs and symptoms of Parkinson disease). A simple test to help non-neurologists identify workers with clinical Mn neurotoxicity represents an unmet need. In ...

journal_title：Neurotoxicology

authors： Racette BA,Gross A,Criswell SR,Checkoway H,Searles Nielsen S

更新日期：2018-01-01 00:00:00

abstract：:Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...

journal_title：Neurotoxicology

authors： Caito S,Park M,Aschner M

更新日期：2017-12-01 00:00:00

abstract：:Bisphenol A (BPA) is a high volume endocrine disrupting chemical found in a wide variety of products including plastics and epoxy resins. Human exposure is nearly ubiquitous, and higher in children than adults. Because BPA has been reported to interfere with sex steroid hormone signaling, there is concern that develop...

journal_title：Neurotoxicology

authors： Arambula SE,Fuchs J,Cao J,Patisaul HB

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Prenatal chemical exposures may adversely affect neurodevelopment, but few studies have examined the persistence of these associations. We examined whether associations between prenatal bisphenol A (BPA) or polybrominated diphenyl ether (PBDE) exposures persist or resolve as children age. METHODS:We followe...

journal_title：Neurotoxicology

authors： Braun JM,Yolton K,Stacy SL,Erar B,Papandonatos GD,Bellinger DC,Lanphear BP,Chen A

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Gestational phthalate exposures have been adversely associated with attention, externalizing, and internalizing behaviors in childhood. Early childhood temperament may be a marker of later behavioral patterns. We therefore sought to determine whether gestational phthalate exposures were associated with inf...

journal_title：Neurotoxicology

authors： Singer AB,Wolff MS,Silva MJ,Calafat AM,Engel SM

更新日期：2017-09-01 00:00:00

abstract：:Several striatal toxins can be used to induce motor disruption. One example is MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), whose toxicity is accepted as a murine model of parkinsonism. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mi...

journal_title：Neurotoxicology

authors： Pérez-Rodríguez M,García-Mendoza E,Farfán-García ED,Das BC,Ciprés-Flores FJ,Trujillo-Ferrara JG,Tamay-Cach F,Soriano-Ursúa MA

更新日期：2017-09-01 00:00:00

abstract：:Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in th...

journal_title：Neurotoxicology

authors： Amaraneni M,Pang J,Mortuza TB,Muralidhara S,Cummings BS,White CA,Vorhees CV,Zastre J,Bruckner JV

更新日期：2017-09-01 00:00:00

abstract：:As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child IQ were collected by trained psychologists. The Wechsler Pre-school and Primary Scale of Intelligence - Revised UK edition (WPPSI) was used at age 4 years in a subsample of children enrolled in ALSPAC (the Children in Focus coho...

journal_title：Neurotoxicology

authors： Taylor CM,Kordas K,Golding J,Emond AM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Nav) channels have not been well-evaluated in all the mammalian Nav isoforms. OBJECTIVE:Here we compare the well-studied ...

journal_title：Neurotoxicology

authors： James TF,Nenov MN,Tapia CM,Lecchi M,Koshy S,Green TA,Laezza F

更新日期：2017-05-01 00:00:00

abstract：:Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG). This occurs at 1.0mg/kg...

journal_title：Neurotoxicology

authors： Carr RL,Armstrong NH,Buchanan AT,Eells JB,Mohammed AN,Ross MK,Nail CA

更新日期：2017-03-01 00:00:00

abstract：:Environmental exposure to methylmercury (MeHg) during development is of concern because it is easily incorporated in children's body both pre- and post-natal, it acts at several levels of neural pathways (mitochondria, cytoskeleton, neurotransmission) and it causes behavioral impairment in child. We evaluated the effe...

journal_title：Neurotoxicology

authors： Caballero B,Olguin N,Campos F,Farina M,Ballester F,Lopez-Espinosa MJ,Llop S,Rodríguez-Farré E,Suñol C

更新日期：2017-03-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants. While the mechanism remains unknown, the potential neurotoxic effects of PBDEs remain a relevant issue. In the present study, neonatal Sprague-Dawley rats of both sexes were administered BDE 209 (1, 10, or 20mg/kg body weight) or peanut oil once d...

journal_title：Neurotoxicology

authors： Li X,Wang C,Wang W,Yue C,Tang Y

更新日期：2017-03-01 00:00:00

abstract：:Perfluoroalkyl and polyfluoroalkyl substances are used in commercial applications and developmental exposure has been implicated in alterations in neurobehavioral functioning. While associations between developmental perfluorooctanoic acid (PFOA) exposure and human outcomes have been inconsistent, studies in experimen...

journal_title：Neurotoxicology

authors： Goulding DR,White SS,McBride SJ,Fenton SE,Harry GJ

更新日期：2017-01-01 00:00:00

abstract：:Development of the mammalian central nervous system is a complex process whose disruption may have severe and long-lasting consequences upon brain structure and function, potentially resulting in a neurodevelopmental disorder (NDD). Many NDDs are known to be genetic in origin, with symptom onset and their underlying m...

journal_title：Neurotoxicology

authors： Heyer DB,Meredith RM

更新日期：2017-01-01 00:00:00

abstract：:The spatial and temporal patterns of spontaneous synchronous Ca2+ oscillations (SCOs) regulate physiological pathways that influence neuronal development, excitability, and health. Hippocampal neuronal cultures (HN) and neuron/glia co-cultures (HNG) produced from neonatal mice were loaded with Fluo-4/AM and SCOs recor...

journal_title：Neurotoxicology

authors： Cao Z,Xu J,Hulsizer S,Cui Y,Dong Y,Pessah IN

更新日期：2017-01-01 00:00:00

abstract：:Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...

journal_title：Neurotoxicology

authors： Ma C,Long H

更新日期：2016-12-01 00:00:00

abstract：:Low-to-moderate level developmental and adult lead exposure produces retinal dysfunction and/or degeneration in humans and experimental animals. Although high level in vivo or in vitro lead disrupts blood-brain-barrier tight junctions and increases its permeability, the blood-retinal-barrier (BRB) has not been examine...

journal_title：Neurotoxicology

authors： Shen XF,Huang P,Fox DA,Lin Y,Zhao ZH,Wang W,Wang JY,Liu XQ,Chen JY,Luo WJ

更新日期：2016-12-01 00:00:00

abstract：:In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB) endothelial function. Immortalized human brain microvascular endothelial cell line (hCMEC/D3) was exposed to azidothymidine (AZT; a nucleoside reverse transcrip...

journal_title：Neurotoxicology

authors： Prasad S,Sajja RK,Kaisar MA,Cucullo L

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...

journal_title：Neurotoxicology

authors： Janelsins MC,Heckler CE,Thompson BD,Gross RA,Opanashuk LA,Cory-Slechta DA

更新日期：2016-09-01 00:00:00

abstract：:Domoic acid is a neurotoxin produced by algae and is found in seafood during harmful algal blooms. As a glutamate agonist, domoic acid inappropriately stimulates excitatory activity in neurons. At high doses, this leads to seizures and brain lesions, but it is unclear how lower, asymptomatic exposures disrupt neuronal...

journal_title：Neurotoxicology

authors： Hiolski EM,Ito S,Beggs JM,Lefebvre KA,Litke AM,Smith DR

更新日期：2016-09-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with a remarkable antitumor activity, used in the clinic as first line treatment for multiple myeloma. One hallmark of bortezomib mechanism of action in neoplastic cells is the inhibition of nuclear factor kappa B (NFκB), a transcription factor involved in cell survival and prolife...

journal_title：Neurotoxicology

authors： Alé A,Bruna J,Calls A,Karamita M,Haralambous S,Probert L,Navarro X,Udina E

更新日期：2016-07-01 00:00:00

abstract：:The Serotonin/Norepinephrine Reuptake Inhibitor (SNRI) antidepressant venlafaxine (VEN, Effexor(®)) has become one of the most common antidepressants detected in North American and European streams. Mammalian research has established that VEN exposure is associated with a range of structural, neurochemical, and functi...

journal_title：Neurotoxicology

authors： Bidel F,Di Poi C,Budzinski H,Pardon P,Callewaert W,Arini A,Basu N,Dickel L,Bellanger C,Jozet-Alves C

更新日期：2016-07-01 00:00:00

abstract：:Mortality and morbidity by toxic metals is an important issue of occupational health. Lead is an ubiquitous heavy metal in our environment despite having no physiological role in biological systems. Being an homeostatic controller is expected that the autonomic nervous system would show a degree of impairment in lead ...

journal_title：Neurotoxicology

authors： Geraldes V,Carvalho M,Goncalves-Rosa N,Tavares C,Laranjo S,Rocha I

更新日期：2016-05-01 00:00:00

abstract：:Tebufenpyrad and pyridaben are two agro-chemically important acaricides that function like the known mitochondrial toxicant rotenone. Although these two compounds have been commonly used to kill populations of mites and ticks in commercial greenhouses, their neurotoxic profiles remain largely unknown. Therefore, we in...

journal_title：Neurotoxicology

authors： Charli A,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:The association between lead exposure and autism spectrum disorder is inconclusive. We hypothesized an association between higher blood lead concentrations and more autistic behaviors, including impaired social interactions and communication, stereotypical behaviors, and restricted interests, among school-...

journal_title：Neurotoxicology

authors： Kim KN,Kwon HJ,Hong YC

更新日期：2016-03-01 00:00:00

abstract：:Mercury (Hg) has many harmful vascular effects by increasing oxidative stress, inflammation and vascular/endothelial dysfunction, all of which may contribute to cerebrovascular diseases development. We aimed to explore the effects of chronic low-mercury concentration on vascular function in cerebral arteries and the m...

journal_title：Neurotoxicology

authors： Wiggers GA,Furieri LB,Briones AM,Avendaño MS,Peçanha FM,Vassallo DV,Salaices M,Alonso MJ

更新日期：2016-03-01 00:00:00

abstract：:The growth and morphological differentiation of neurons are critical events in the establishment of proper neuronal connectivity and functioning. The developing nervous system is highly susceptible to damage caused by exposure to environmental contaminants. Glyphosate-containing herbicides are the most used agrochemic...

journal_title：Neurotoxicology

authors： Coullery RP,Ferrari ME,Rosso SB

更新日期：2016-01-01 00:00:00

abstract：:We have evidence that methamphetamine (METH)-induced neuronal death is morphologically necrotic, not apoptotic, as is currently believed, and that electrographic seizures may be responsible. We administered 40mg/kg i.p. to 12 male C57BL/6 mice and monitored EEGs continuously and rectal temperatures every 15min, keepin...

journal_title：Neurotoxicology

authors： Fujikawa DG,Pais ES,Aviles ER Jr,Hsieh KC,Bashir MT

更新日期：2016-01-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway. In humans, perinatal exposure to dioxin-like PCBs is associated with neurodevelopmental toxicity in child...

journal_title：Neurotoxicology

authors： Glazer L,Hahn ME,Aluru N

更新日期：2016-01-01 00:00:00